Project details: The mechanisms by which Dormant Cancer cells (DCC) survive and later proliferate are poorly understood. We are investigating the hidden links between EMT (Epithelial-Mesenchymal Transition) and DCC. Also, I led and contributed to various diverse projects of the lab.

Advisor: Dr. Mohit Kumar Jolly (IISc) 

Collaborative work: 

Duke Comparative Oncology Group, Duke Cancer Institute, Durham, USA

Projects details: 

➜ The therapy resistance to prostate cancer is a global concern, and it is mediated by diverse mechanisms. The experimental group investigated the EMT-mediated hormone therapy resistants. I performed the meta-analysis of RNA-seq data and calculated the nature of EMT.

➜ I was part of exploring ELF3 transcription factors and their associated EMT with computational approaches.

Advisors: Dr. Jason Somarelli (Duke), Dr. Mohit Kumar Jolly (IISc)

Project details: The activation of the fibrinolytic system is important in vascular hemostatic mechanisms and intense tissue damage. We studied structures of key protein targets, then screened potential compounds using various computational tools and M.D Simulation

Advisors: Dr. K Sekar (IISc), Dr. Prosenjit Sen (IACS)

Project details: The heavy metals and microbial contaminants in water bodies are a great threat to the environment and human health. We have designed two economic materials 

(i) A Cu-based absorbent for heavy metals removal 

(ii) A novel Ca-MOF for dual action against heavy metals and microbial contaminants removal

Advisors: Dr. Suresh Gupta, Dr. Jitendra Panwar